منابع مشابه
Connecting type 1 and type 2 diabetes through innate immunity.
The escalating epidemic of obesity has driven the prevalence of both type 1 and 2 diabetes mellitus to historically high levels. Chronic low-grade inflammation, which is present in both type 1 and type 2 diabetics, contributes to the pathogenesis of insulin resistance. The accumulation of activated innate immune cells in metabolic tissues results in release of inflammatory mediators, in particu...
متن کاملInnate and adaptive autoimmunity in type 1 diabetes.
Morran MP, McInerney MF, Pietropaolo M. Innate and adaptive autoimmunity in type 1 diabetes. Pediatric Diabetes 2008: 9: 152–161. Michael P Morran, Marcia F McInerney and Massimo Pietropaolo Laboratory of Immunogenetics, The Brehm Center for Type 1 Diabetes Research and Analysis, Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical Sc...
متن کاملInnate Viral Receptor Signaling Determines Type 1 Diabetes Onset
Heritable susceptibility of the autoimmune disorder, type 1 diabetes (T1D), only partially equates for the incidence of the disease. Significant evidence attributes several environmental stressors, such as vitamin D deficiency, gut microbiome, dietary antigens, and most notably virus infections in triggering the onset of T1D in these genetically susceptible individuals. Extensive epidemiologica...
متن کاملFiber intake and inflammation in type 1 diabetes
BACKGROUND Higher intake of dietary fiber is associated with lower risk of coronary heart disease, the leading cause of mortality among people with type 1 diabetes. The protective effect includes the anti-inflammatory properties of some foods. Population-based studies have shown an inverse association between some nutritional habits and high sensitive -C-reactive protein (hs-CRP). This study ai...
متن کاملImaging inflammation of the pancreatic islets in type 1 diabetes.
Type 1 diabetes is the clinical manifestation of aberrant leukocytic infiltration of the pancreatic islets; it is usually diagnosed only very late in disease progression, after the critical autoimmune phenomena have mostly played out. A noninvasive means of directly monitoring the evolution of islet infiltrates would have important research and clinical applications. We have exploited fluoresce...
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ژورنال
عنوان ژورنال: Translational Research
سال: 2016
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2015.04.011